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This is a category for people from Nix family bloodline. Once triggered, the Nix Trouble involves rapid organ death. The only way that anyone with this Trouble can survive is to attack others and steal their organs. A long thin snake-like creature comes out of the Troubled person's mouth, and goes down the throat of the victim, taking the needed organ and replacing it inside their body. The Troubled person then coughs up their old, dead organ. Harry Nix's Trouble was first triggered in his childhood, when his father attempted to kill him for his organs. Knowing that the Troubles would return, he obtained a job at Haven's Hope, where he switched out the semen that clients provided for his own, ensuring that when the time came, he'd have many family members to take organs from.

Marjean Nix, Harry's wife, shares the Nix family name, but not it's bloodline, and is therefore, not Troubled. When Duke Crocker killed Harry Nix, he took the Nix family Trouble, healing the many patients who were dying from organ death caused by the Nix Trouble.

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